Lipin-1 Phosphatidic Phosphatase Activity Modulates Phosphatidate Levels to Promote Peroxisome Proliferator-activated Receptor γ (PPARγ) Gene Expression during Adipogenesis

Adipose tissue plays a key role in metabolic homeostasis. Disruption of the Lpin1 gene encoding lipin-1 causes impaired adipose tissue development and function in rodents. Lipin-1 functions as a phosphatidate phosphatase (PAP) enzyme in the glycerol 3-phosphate pathway for triglyceride storage and a...

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Bibliographic Details
Main Authors: Zhang, Peixiang, Takeuchi, Kazuharu, Csaki, Lauren S., Reue, Karen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271002/
https://ncbi.nlm.nih.gov/pubmed/22157014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296681
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