B Lymphocytes Promote Insulin Resistance through Modulation of T Lymphocytes and Production of Pathogenic IgG Antibody

Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose tissue (VAT) is a hallmark of obesity associated insulin resistance and glucose intolerance. Here we demonstrate a fundamental pathogenic role for B cells in the development of these metabolic abnormalities....

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Main Authors: Winer, Daniel A., Winer, Shawn, Shen, Lei, Wadia, Persis P., Yantha, Jason, Paltser, Geoffrey, Tsui, Hubert, Wu, Ping, Davidson, Matthew G., Alonso, Michael N., Leong, Hweixian, Glassford, Alec, Caimol, Maria, Kenkel, Justin A., Tedder, Thomas F., McLaughlin, Tracey, Miklos, David B, Dosch, H.-Michael, Engleman, Edgar G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270885/
https://ncbi.nlm.nih.gov/pubmed/21499269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2353
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