B Lymphocytes Promote Insulin Resistance through Modulation of T Lymphocytes and Production of Pathogenic IgG Antibody

Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose tissue (VAT) is a hallmark of obesity associated insulin resistance and glucose intolerance. Here we demonstrate a fundamental pathogenic role for B cells in the development of these metabolic abnormalities....

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主要な著者: Winer, Daniel A., Winer, Shawn, Shen, Lei, Wadia, Persis P., Yantha, Jason, Paltser, Geoffrey, Tsui, Hubert, Wu, Ping, Davidson, Matthew G., Alonso, Michael N., Leong, Hweixian, Glassford, Alec, Caimol, Maria, Kenkel, Justin A., Tedder, Thomas F., McLaughlin, Tracey, Miklos, David B, Dosch, H.-Michael, Engleman, Edgar G.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270885/
https://ncbi.nlm.nih.gov/pubmed/21499269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2353
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