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Loss of imprinting and marked gene elevation are two forms of aberrant IGF2 expression in colorectal cancer

Loss of imprinting (LOI) of IGF2 is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic IGF2 expression correlates strongly with the hypomethylation of a differentially methylated region (DMR) near its promoter. It has also been shown that I...

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Bibliografische gegevens
Hoofdauteurs: Cheng, Yu-Wei, Idrees, Kamran, Shattock, Richard, Khan, Sajid A., Zeng, Zhaoshi, Brennan, Cameron W., Paty, Philip, Barany, Francis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270092/
https://ncbi.nlm.nih.gov/pubmed/19957330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25086
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