p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia

BACKGROUND: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185(BCR/ABL) or the p210(BCR/ABL) fusion proteins are encoded as a result of the translocation, depending on wheth...

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Bibliographische Detailangaben
Hauptverfasser: Mian, Afsar A., Metodieva, Anna, Najajreh, Yousef, Ottmann, Oliver G., Mahajna, Jamal, Ruthardt, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2012
Schlagworte:
Original Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269486/
https://ncbi.nlm.nih.gov/pubmed/22058195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.047191
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