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EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis

The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is unknown. Using a murine model with EGFR-defici...

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Autors principals: Chen, Jianchun, Chen, Jian-Kang, Nagai, Kojiro, Plieth, David, Tan, Mingqi, Lee, Tang-Cheng, Threadgill, David W., Neilson, Eric G., Harris, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269185/
https://ncbi.nlm.nih.gov/pubmed/22095949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011070645
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