EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis

The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is unknown. Using a murine model with EGFR-defici...

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Detalhes bibliográficos
Main Authors: Chen, Jianchun, Chen, Jian-Kang, Nagai, Kojiro, Plieth, David, Tan, Mingqi, Lee, Tang-Cheng, Threadgill, David W., Neilson, Eric G., Harris, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269185/
https://ncbi.nlm.nih.gov/pubmed/22095949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011070645
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