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EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis

The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is unknown. Using a murine model with EGFR-defici...

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書誌詳細
主要な著者: Chen, Jianchun, Chen, Jian-Kang, Nagai, Kojiro, Plieth, David, Tan, Mingqi, Lee, Tang-Cheng, Threadgill, David W., Neilson, Eric G., Harris, Raymond C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269185/
https://ncbi.nlm.nih.gov/pubmed/22095949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011070645
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