Sirtuins and Disease: The Road Ahead

Sirtuins represent a promising new class of conserved histone deacetylases, originally identified in yeast. The activity of the sirtuin (SirT) family – made up of seven members (SirT1-7) – is NAD(+) dependent. Sirtuins target a wide range of cellular proteins in nucleus, cytoplasm, and mitochondria...

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Bibliographic Details
Main Authors: Carafa, Vincenzo, Nebbioso, Angela, Altucci, Lucia
Format: Artigo
Language:Inglês
Published: Frontiers Research Foundation 2012
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269041/
https://ncbi.nlm.nih.gov/pubmed/22319497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00004
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