Transcription Factor NF-κB Regulates Expression of Pore-forming Ca(2+) Channel Unit, Orai1, and Its Activator, STIM1, to Control Ca(2+) Entry and Affect Cellular Functions

The serum and glucocorticoid-inducible kinase SGK1 increases the activity of Orai1, the pore forming unit of store-operated Ca(2+) entry, and thus influences Ca(2+)-dependent cellular functions such as migration. SGK1 further regulates transcription factor nuclear factor κB (NF-κB). This study explo...

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Autors principals: Eylenstein, Anja, Schmidt, Sebastian, Gu, Shuchen, Yang, Wenting, Schmid, Evi, Schmidt, Eva-Maria, Alesutan, Ioana, Szteyn, Kalina, Regel, Ivonne, Shumilina, Ekaterina, Lang, Florian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268429/
https://ncbi.nlm.nih.gov/pubmed/22110130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275925
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