Activation of Wnt Signaling by Chemically Induced Dimerization of LRP5 Disrupts Cellular Homeostasis

Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of Wnt signaling in vivo would be extremely useful. By applying chemical inducer of dimerization (CID)...

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Autors principals: Shahi, Payam, Park, Dongsu, Pond, Adam C., Seethammagari, Mamatha, Chiou, Shin-Heng, Cho, Kyucheol, Carstens, Julienne L., Decker, William K., McCrea, Pierre D., Ittmann, Michael M., Rosen, Jeffrey M., Spencer, David M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267738/
https://ncbi.nlm.nih.gov/pubmed/22303459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030814
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