Inhibition of homologous recombination by the PCNA-interacting protein PARI

Inappropriate homologous recombination (HR) causes genomic instability and cancer. In yeast, the UvrD family helicase Srs2 is recruited to sites of DNA replication by SUMO-modified PCNA, where it acts to restrict HR by disassembling toxic RAD51 nucleofilaments. How human cells control recombination...

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Bibliografiske detaljer
Main Authors: Moldovan, George-Lucian, Dejsuphong, Donniphat, Petalcorin, Mark I. R., Hofmann, Kay, Takeda, Shunichi, Boulton, Simon J., D’Andrea, Alan D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267324/
https://ncbi.nlm.nih.gov/pubmed/22153967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.11.010
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