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Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents
Using haloperidol as a scaffold, new agents were designed to investigate the structural contributions of various groups to binding at CNS receptors associated with atypical antipsychotic pharmacology. It is clear that each pharmacophoric group, the butyrophenone, the piperidine and the 4-chloropheny...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3267002/ https://ncbi.nlm.nih.gov/pubmed/22245230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.12.019 |
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