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THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL

Voltage-gated sodium channels initiate electrical signaling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity, and drug block is unknown. Here, we report the crystal structure of a voltag...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Payandeh, Jian, Scheuer, Todd, Zheng, Ning, Catterall, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266868/
https://ncbi.nlm.nih.gov/pubmed/21743477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10238
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