Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

Increased expression of the regulatory subunit of HIFs (HIF-1α or HIF-2α) is associated with metabolic adaptation, angiogenesis, and tumor progression. Understanding how HIFs are regulated is of intense interest. Intriguingly, the molecular mechanisms that link mitochondrial function with the HIF-re...

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Detalhes bibliográficos
Main Authors: Yang, Jun, Staples, Oliver, Thomas, Luke W., Briston, Thomas, Robson, Mathew, Poon, Evon, Simões, Maria L., El-Emir, Ethaar, Buffa, Francesca M., Ahmed, Afshan, Annear, Nicholas P., Shukla, Deepa, Pedley, Barbara R., Maxwell, Patrick H., Harris, Adrian L., Ashcroft, Margaret
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266784/
https://ncbi.nlm.nih.gov/pubmed/22214851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58780
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