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Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma

Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Sachdeva, Uma M., O’Brien, Joan M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266776/
https://ncbi.nlm.nih.gov/pubmed/22293180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57114
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