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Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma
Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266776/ https://ncbi.nlm.nih.gov/pubmed/22293180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57114 |
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