Chk2 deficiency in Myc-overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition

Myc is a transcription factor frequently found deregulated in human cancer. The Myc-mediated cellular transformation process is associated with fast proliferative cells and inherent genomic instability, giving rise to malignant, invasive neoplasms with poor prognosis for survival. Transcription-inde...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Höglund, Andreas, Strömvall, Kerstin, Li, Yongmei, Forshell, Linus Plym, Nilsson, Jonas A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2011
Pynciau:
Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266184/
https://ncbi.nlm.nih.gov/pubmed/22030621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.20.17887
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