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Chk2 deficiency in Myc-overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition
Myc is a transcription factor frequently found deregulated in human cancer. The Myc-mediated cellular transformation process is associated with fast proliferative cells and inherent genomic instability, giving rise to malignant, invasive neoplasms with poor prognosis for survival. Transcription-inde...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266184/ https://ncbi.nlm.nih.gov/pubmed/22030621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.20.17887 |
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