Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-overexpressing Lymphoma

BACKGROUND: Aberrant Myc expression plays a critical role in various tumors, including non-Hodgkin lymphoma (NHL). Myc-positive lymphoma is clinically aggressive, more resistant to chemotherapy, and associated with high mortality. OBJECTIVE: The current study aimed to show inhibition of aurora A kin...

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Detalhes bibliográficos
Publicado no:Target Oncol
Main Authors: Park, Steven I., Lin, Carolina P., Ren, Natalie, Angus, Steven P., Dittmer, Dirk P., Foote, Michael, Parton, Trevor, Bhatt, Aadra P., Fedoriw, Yuri D., Roth, Daniel P., Cann, Marissa L., Johnson, Gary L., Damania, Blossom
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893856/
https://ncbi.nlm.nih.gov/pubmed/31429028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-019-00662-4
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