Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-overexpressing Lymphoma

BACKGROUND: Aberrant Myc expression plays a critical role in various tumors, including non-Hodgkin lymphoma (NHL). Myc-positive lymphoma is clinically aggressive, more resistant to chemotherapy, and associated with high mortality. OBJECTIVE: The current study aimed to show inhibition of aurora A kin...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Target Oncol
Main Authors: Park, Steven I., Lin, Carolina P., Ren, Natalie, Angus, Steven P., Dittmer, Dirk P., Foote, Michael, Parton, Trevor, Bhatt, Aadra P., Fedoriw, Yuri D., Roth, Daniel P., Cann, Marissa L., Johnson, Gary L., Damania, Blossom
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893856/
https://ncbi.nlm.nih.gov/pubmed/31429028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-019-00662-4
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares