Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions

Background. Preclinical evaluation of tuberculosis drugs is generally limited to mice. However, necrosis and hypoxia, key features of human tuberculosis lesions, are lacking in conventional mouse strains. Methods. We used C3HeB/FeJ mice, which develop necrotic lesions in response to Mycobacterium tu...

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Detalhes bibliográficos
Main Authors: Harper, Jamie, Skerry, Ciaran, Davis, Stephanie L., Tasneen, Rokeya, Weir, Mariah, Kramnik, Igor, Bishai, William R., Pomper, Martin G., Nuermberger, Eric L., Jain, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266133/
https://ncbi.nlm.nih.gov/pubmed/22198962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir786
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