Characterization of a Novel Necrotic Granuloma Model of Latent Tuberculosis Infection and Reactivation in Mice

We sought to develop and characterize a novel paucibacillary model in mice, which develops necrotic lung granulomas after infection with Mycobacterium tuberculosis. Six weeks after aerosol immunization with recombinant Mycobacterium bovis bacillus Calmette-Guerin overexpressing the 30-kDa antigen, C...

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Bibliographic Details
Main Authors: Dutta, Noton K., Illei, Peter B., Jain, Sanjay K., Karakousis, Petros C.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2014
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076462/
https://ncbi.nlm.nih.gov/pubmed/24815353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.03.008
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