Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas

Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune responses to Mycobacterium tuberculosis infection, macrophage recruitment and granuloma formation. We evaluated whether adjunctive inhibition of MMP-9 could improve the response to standard TB treatment in a m...

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Udgivet i:PLoS One
Main Authors: Ordonez, Alvaro A., Pokkali, Supriya, Kim, Sunhwa, Carr, Brian, Klunk, Mariah H., Tong, Leah, Saini, Vikram, Chang, Yong S., McKevitt, Matthew, Smith, Victoria, Gossage, David L., Jain, Sanjay K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951562/
https://ncbi.nlm.nih.gov/pubmed/29758082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197474
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