Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions

Background. Preclinical evaluation of tuberculosis drugs is generally limited to mice. However, necrosis and hypoxia, key features of human tuberculosis lesions, are lacking in conventional mouse strains. Methods. We used C3HeB/FeJ mice, which develop necrotic lesions in response to Mycobacterium tu...

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Hlavní autoři: Harper, Jamie, Skerry, Ciaran, Davis, Stephanie L., Tasneen, Rokeya, Weir, Mariah, Kramnik, Igor, Bishai, William R., Pomper, Martin G., Nuermberger, Eric L., Jain, Sanjay K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266133/
https://ncbi.nlm.nih.gov/pubmed/22198962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir786
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