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The Protein Farnesyltransferase Inhibitor Tipifarnib as a new Lead for the Development of Drugs against Chagas Disease

Tipifarnib (R115777), an inhibitor of human protein farnesyltransferase (PFT), is shown to be a highly potent inhibitor of Trypanosoma cruzi growth (ED50 = 4 nM). Surprisingly, this is due to the inhibition of cytochrome P450 sterol 14-demethylase (CYP51, EC 1.14.13.70). Homology models of the T. cr...

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Bibliografiske detaljer
Main Authors: Hucke, Oliver, Gelb, Michael H., Verlinde, Christophe L. M. J., Buckner, Frederick S.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265986/
https://ncbi.nlm.nih.gov/pubmed/16107140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050441z
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