Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 Integrin Mediates Interaction of Melanoma Cells with Platelets: A CONNECTION TO HEMATOGENOUS METASTASIS

A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here, we used murine B16 melanoma cells to observe functional aspects of how platele...

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Detalhes bibliográficos
Main Authors: Lonsdorf, Anke S., Krämer, Björn F., Fahrleitner, Manuela, Schönberger, Tanja, Gnerlich, Stephan, Ring, Sabine, Gehring, Sarah, Schneider, Stefan W., Kruhlak, Michael J., Meuth, Sven G., Nieswandt, Bernhard, Gawaz, Meinrad, Enk, Alexander H., Langer, Harald F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265895/
https://ncbi.nlm.nih.gov/pubmed/22102277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.269811
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