Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol in two NAD(+)-dependent steps. The catalytic reaction of UGDH is thought to involve a Cys nucleophile that promotes formation of a thiohemiacetal...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Egger, Sigrid, Chaikuad, Apirat, Klimacek, Mario, Kavanagh, Kathryn L., Oppermann, Udo, Nidetzky, Bernd
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2012
विषय:
Enzymology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265891/
https://ncbi.nlm.nih.gov/pubmed/22123821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313015
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