Structure and Mechanism of Human UDP-xylose Synthase: EVIDENCE FOR A PROMOTING ROLE OF SUGAR RING DISTORTION IN A THREE-STEP CATALYTIC CONVERSION OF UDP-GLUCURONIC ACID

UDP-xylose synthase (UXS) catalyzes decarboxylation of UDP-d-glucuronic acid to UDP-xylose. In mammals, UDP-xylose serves to initiate glycosaminoglycan synthesis on the protein core of extracellular matrix proteoglycans. Lack of UXS activity leads to a defective extracellular matrix, resulting in st...

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Bibliographic Details
Main Authors: Eixelsberger, Thomas, Sykora, Sabine, Egger, Sigrid, Brunsteiner, Michael, Kavanagh, Kathryn L., Oppermann, Udo, Brecker, Lothar, Nidetzky, Bernd
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438964/
https://ncbi.nlm.nih.gov/pubmed/22810237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386706
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