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Crystallographic snapshots of UDP-glucuronic acid 4-epimerase ligand binding, rotation, and reduction

UDP-glucuronic acid is converted to UDP-galacturonic acid en route to a variety of sugar-containing metabolites. This reaction is performed by a NAD(+)-dependent epimerase belonging to the short-chain dehydrogenase/reductase family. We present several high-resolution crystal structures of the UDP-gl...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Iacovino, Luca Giacinto, Savino, Simone, Borg, Annika J. E., Binda, Claudia, Nidetzky, Bernd, Mattevi, Andrea
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458814/
https://ncbi.nlm.nih.gov/pubmed/32661196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014692
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