Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol in two NAD(+)-dependent steps. The catalytic reaction of UGDH is thought to involve a Cys nucleophile that promotes formation of a thiohemiacetal...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Egger, Sigrid, Chaikuad, Apirat, Klimacek, Mario, Kavanagh, Kathryn L., Oppermann, Udo, Nidetzky, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265891/
https://ncbi.nlm.nih.gov/pubmed/22123821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados