Polyglutamine Expansion Alters the Dynamics and Molecular Architecture of Aggregates in Dentatorubropallidoluysian Atrophy

Preferential accumulation of mutant proteins in the nucleus has been suggested to be the molecular culprit that confers cellular toxicity in the neurodegenerative disorders caused by polyglutamine (polyQ) expansion. Here, we use dynamic imaging approaches, orthogonal cross-seeding, and composition a...

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Bibliografiske detaljer
Main Authors: Hinz, Justyna, Lehnhardt, Lothar, Zakrzewski, Silke, Zhang, Gong, Ignatova, Zoya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265886/
https://ncbi.nlm.nih.gov/pubmed/22134925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318915
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