Polyglutamine Expansion Alters the Dynamics and Molecular Architecture of Aggregates in Dentatorubropallidoluysian Atrophy

Preferential accumulation of mutant proteins in the nucleus has been suggested to be the molecular culprit that confers cellular toxicity in the neurodegenerative disorders caused by polyglutamine (polyQ) expansion. Here, we use dynamic imaging approaches, orthogonal cross-seeding, and composition a...

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Main Authors: Hinz, Justyna, Lehnhardt, Lothar, Zakrzewski, Silke, Zhang, Gong, Ignatova, Zoya
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265886/
https://ncbi.nlm.nih.gov/pubmed/22134925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318915
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