Architecture of Polyglutamine-containing Fibrils from Time-resolved Fluorescence Decay

The disease risk and age of onset of Huntington disease (HD) and nine other repeat disorders strongly depend on the expansion of CAG repeats encoding consecutive polyglutamines (polyQ) in the corresponding disease protein. PolyQ length-dependent misfolding and aggregation are the hallmarks of CAG pa...

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Bibliografiske detaljer
Main Authors: Röthlein, Christoph, Miettinen, Markus S., Borwankar, Tejas, Bürger, Jörg, Mielke, Thorsten, Kumke, Michael U., Ignatova, Zoya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175324/
https://ncbi.nlm.nih.gov/pubmed/25092288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581991
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