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Architecture of Polyglutamine-containing Fibrils from Time-resolved Fluorescence Decay
The disease risk and age of onset of Huntington disease (HD) and nine other repeat disorders strongly depend on the expansion of CAG repeats encoding consecutive polyglutamines (polyQ) in the corresponding disease protein. PolyQ length-dependent misfolding and aggregation are the hallmarks of CAG pa...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175324/ https://ncbi.nlm.nih.gov/pubmed/25092288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581991 |
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