Architecture of Polyglutamine-containing Fibrils from Time-resolved Fluorescence Decay

The disease risk and age of onset of Huntington disease (HD) and nine other repeat disorders strongly depend on the expansion of CAG repeats encoding consecutive polyglutamines (polyQ) in the corresponding disease protein. PolyQ length-dependent misfolding and aggregation are the hallmarks of CAG pa...

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Detalhes bibliográficos
Main Authors: Röthlein, Christoph, Miettinen, Markus S., Borwankar, Tejas, Bürger, Jörg, Mielke, Thorsten, Kumke, Michael U., Ignatova, Zoya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175324/
https://ncbi.nlm.nih.gov/pubmed/25092288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581991
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