Glucose and Insulin Induction of Bile Acid Synthesis: MECHANISMS AND IMPLICATION IN DIABETES AND OBESITY

Bile acids facilitate postprandial absorption of nutrients. Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 and play a major role in regulating lipid, glucose, and energy metabolism. Transgenic expression of cholesterol 7α-hydroxylase (CYP7A1) prevente...

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Hlavní autoři: Li, Tiangang, Francl, Jessica M., Boehme, Shannon, Ochoa, Adrian, Zhang, Youcai, Klaassen, Curtis D., Erickson, Sandra K., Chiang, John Y. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265867/
https://ncbi.nlm.nih.gov/pubmed/22144677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.305789
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