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Decreased Bile-Acid Synthesis in Livers of Hepatocyte-Conditional NADPH–Cytochrome P450 Reductase–Null Mice Results in Increased Bile Acids in Serum

NADPH–cytochrome P450 reductase (Cpr) is essential for the function of microsomal cytochrome P450 monooxygenases (P450), including those P450s involved in bile acid (BA) synthesis. Mice with hepatocyte-specific deletion of NADPH–cytochrome P450 reductase (H-Cpr-null) have been engineered to understa...

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Detalhes bibliográficos
Main Authors: Cheng, Xingguo, Zhang, Youcai, Klaassen, Curtis D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165027/
https://ncbi.nlm.nih.gov/pubmed/25034404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.216796
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