Fructose Protects Murine Hepatocytes from Tumor Necrosis Factor-induced Apoptosis by Modulating JNK Signaling

Fructose-induced hepatic ATP depletion prevents TNF-induced apoptosis, whereas it contrarily enhances CD95-induced hepatocyte apoptosis in vitro and in vivo. By contrast, transformed liver cells are not protected against TNF due to metabolic alterations, allowing selective tumor targeting. We analyz...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Speicher, Tobias, Köhler, Ulrike A., Choukèr, Alexander, Werner, Sabine, Weiland, Timo, Wendel, Albrecht
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Metabolism
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265865/
https://ncbi.nlm.nih.gov/pubmed/22086922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.266742
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