Fructose Protects Murine Hepatocytes from Tumor Necrosis Factor-induced Apoptosis by Modulating JNK Signaling

Fructose-induced hepatic ATP depletion prevents TNF-induced apoptosis, whereas it contrarily enhances CD95-induced hepatocyte apoptosis in vitro and in vivo. By contrast, transformed liver cells are not protected against TNF due to metabolic alterations, allowing selective tumor targeting. We analyz...

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Main Authors: Speicher, Tobias, Köhler, Ulrike A., Choukèr, Alexander, Werner, Sabine, Weiland, Timo, Wendel, Albrecht
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Metabolism
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265865/
https://ncbi.nlm.nih.gov/pubmed/22086922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.266742
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