Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant

The hypomethylating agent 5-azacytidine (5AC) is widely used in patients at risk of invasive mycoses. We sought to determine whether 5AC affects the developmental competence and virulence of Aspergillus fumigatus. Incubation of A. fumigatus strain 293 with 5AC induced high-frequency conversion to a...

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Bibliographic Details
Main Authors: Ben-Ami, Ronen, Varga, John, Lewis, Russell E, May, Gregory S, Nierman, William C, Kontoyiannis, Dimitrios P
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2010
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265789/
https://ncbi.nlm.nih.gov/pubmed/21178435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/viru.1.3.11750
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