Extra Copies of the Aspergillus fumigatus Squalene Epoxidase Gene Confer Resistance to Terbinafine: Genetic Approach to Studying Gene Dose-Dependent Resistance to Antifungals in A. fumigatus

With the increasing use of antifungals such as amphotericin B, itraconazole, voriconazole, caspofungin, and terbinafine (TRB) in patients at high risk for invasive aspergillosis, resistance of Aspergillus fumigatus to these agents will ultimately emerge. Due to the limited availability of molecular...

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Detalhes bibliográficos
Main Authors: Liu, Wei, May, Gregory S., Lionakis, Michail S., Lewis, Russell E., Kontoyiannis, Dimitrios P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC434218/
https://ncbi.nlm.nih.gov/pubmed/15215099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2490-2496.2004
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