Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant

The hypomethylating agent 5-azacytidine (5AC) is widely used in patients at risk of invasive mycoses. We sought to determine whether 5AC affects the developmental competence and virulence of Aspergillus fumigatus. Incubation of A. fumigatus strain 293 with 5AC induced high-frequency conversion to a...

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Hauptverfasser: Ben-Ami, Ronen, Varga, John, Lewis, Russell E, May, Gregory S, Nierman, William C, Kontoyiannis, Dimitrios P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2010
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265789/
https://ncbi.nlm.nih.gov/pubmed/21178435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/viru.1.3.11750
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