The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor

The major obstacle in platinum chemotherapy is the repair of platinum-damaged DNA that results in increased resistance, reduced apoptosis, and finally treatment failure. Our research goal is to determine and block the mechanisms of platinum resistance. Our recent studies demonstrate that several kin...

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Detalhes bibliográficos
Main Authors: Liang, Xiaobing, Guo, Yi, Figg, William Douglas, Fojo, Antonio Tito, Mueller, Michael D., Yu, Jing Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265242/
https://ncbi.nlm.nih.gov/pubmed/22312557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/715469
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