Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin

BACKGROUND: Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by the sudden depletion of paracrine growth stimulation. METHODS: The effects of se...

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Bibliografiske detaljer
Main Authors: Shi, Yandong, Felley-Bosco, Emanuela, Marti, Thomas M, Orlowski, Katrin, Pruschy, Martin, Stahel, Rolf A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527202/
https://ncbi.nlm.nih.gov/pubmed/23211021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-571
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