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Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain
The tumour suppressor p53 is a tetrameric protein that is phosphorylated in its BOX-I transactivation domain by checkpoint kinase 2 (CHK2) in response to DNA damage. CHK2 cannot phosphorylate small peptide fragments of p53 containing the BOX-I motif, indicating that undefined determinants in the p53...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1326341/ https://ncbi.nlm.nih.gov/pubmed/12897801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor901 |
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