Age-Dependent Cardiomyopathy in Mitochondrial Mutator Mice is Attenuated by Overexpression of Catalase Targeted to Mitochondria

Mitochondrial defects have been found in aging and several age-related diseases. Mice with a homozygous mutation in the exonuclease encoding domain of mitochondrial DNA polymerase gamma (Polg(m/m)) are prone to age-dependent accumulation of mitochondrial DNA mutations and have shown a broad spectrum...

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Bibliographic Details
Main Authors: Dai, Dao-Fu, Chen, Tony, Wanagat, Jonathan, Laflamme, Michael, Marcinek, David J., Emond, Mary J, Ngo, Calvin P., Prolla, Tomas A., Rabinovitch, Peter S.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265170/
https://ncbi.nlm.nih.gov/pubmed/20456298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2010.00581.x
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