Mitochondrial oxidative stress mediates Angiotensin II-induced cardiac hypertrophy and Gαq overexpression-induced heart failure

RATIONALE: Mitochondrial dysfunction has been implicated in several cardiovascular diseases; however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive cardiomyopathy are not well understood. OBJECTIVE: We evaluated the contribution of mitochondrial reactive oxygen species (...

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Detalhes bibliográficos
Main Authors: Dai, Dao-Fu, Johnson, Simon C., Villarin, Jason J., Chin, Michael T., Nieves-Cintrón, Madeline, Chen, Tony, Marcinek, David J., Dorn, Gerald W., Kang, Y. James, Prolla, Tomas A., Santana, Luis F., Rabinovitch, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785241/
https://ncbi.nlm.nih.gov/pubmed/21311045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.232306
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