Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors

Aurora kinases are a family of mitotic kinases that play important roles in the tumorigenesis of a variety of cancers including pancreatic cancer. A number of Aurora kinase inhibitors (AKIs) are currently being tested in preclinical and clinical settings as anti-cancer therapies. However, the antitu...

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Autori principali: Xie, Lifang, Kassner, Michelle, Munoz, Ruben M., Que, Quick, Kiefer, Jeff, Zhao, Yu, Mousses, Spyro, Yin, Holly, Von Hoff, Daniel D., Han, Haiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265162/
https://ncbi.nlm.nih.gov/pubmed/22100984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.11.005
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