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Pdx-1-Driven Overexpression of Aurora A Kinase Induces Mild Ductal Dyplasia of Pancreatic Ducts Near Islets in Transgenic Mice

OBJECTIVES: To further explore the oncogenic activity of Aurora A kinase while attempting to develop a useful mouse model for pancreatic cancer, Aurora A kinase was targeted to Pdx-1 positive cells. METHODS: Aurora A kinase overexpression was targeted to mouse pancreas tissue using the Pdx-1 promote...

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Bibliografske podrobnosti
Main Authors: Warner, Steven L., Muñoz, Ruben M., Bearss, David J., Grippo, Paul, Han, Haiyong, Von Hoff, Daniel D.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728596/
https://ncbi.nlm.nih.gov/pubmed/18815537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e318176b9ae
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