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Pdx-1-Driven Overexpression of Aurora A Kinase Induces Mild Ductal Dyplasia of Pancreatic Ducts Near Islets in Transgenic Mice
OBJECTIVES: To further explore the oncogenic activity of Aurora A kinase while attempting to develop a useful mouse model for pancreatic cancer, Aurora A kinase was targeted to Pdx-1 positive cells. METHODS: Aurora A kinase overexpression was targeted to mouse pancreas tissue using the Pdx-1 promote...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728596/ https://ncbi.nlm.nih.gov/pubmed/18815537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e318176b9ae |
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