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Degradability of Poly(lactic acid)-containing Nanoparticles: Enzymatic access through a crosslinked shell barrier

Comparative studies of bulk samples of hydrolytically-degradable poly(lactic acid) (PLA) vs. core-shell block copolymer micelles having PLA cores revealed remarkable acceleration in the proteinase K enzymatic hydrolysis of the nanoparticulate forms, and demonstrated that even with amidation-based sh...

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Autori principali: Samarajeewa, Sandani, Shrestha, Ritu, Li, Yali, Wooley, Karen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265020/
https://ncbi.nlm.nih.gov/pubmed/22257265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2095602
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