The γ-secretase cleavage product of Polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism

Mutations in Pkd1, encoding polycystin-1 (PC1), cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disr...

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Главные авторы: Merrick, David, Chapin, Hannah, Baggs, Julie E., Yu, Zhiheng, Somlo, Stefan, Sun, Zhaoxia, Hogenesch, John B., Caplan, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264829/
https://ncbi.nlm.nih.gov/pubmed/22178500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.10.028
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