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Hot spot analysis for driving the development of hits into leads in fragment based drug discovery
Fragment based drug design (FBDD) starts with finding fragment-sized compounds that are highly ligand efficient and can serve as a core moiety for developing high affinity leads. Although the core-bound structure of a protein facilitates the construction of leads, effective design is far from straig...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3264775/ https://ncbi.nlm.nih.gov/pubmed/22145575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci200468p |
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