In Vitro and In Vivo Investigation of the Efficacy of Arylimidamide DB1831 and Its Mesylated Salt Form - DB1965 - against Trypanosoma cruzi Infection

Chagas disease is caused by infection with the intracellular protozoan parasite Trypanosoma cruzi. At present, nifurtimox and benznidazole, both compounds developed empirically over four decades ago, represent the chemotherapeutic arsenal for treating this highly neglected disease. However, both dru...

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Main Authors: da Silva, Cristiane França, Batista, Denise da Gama Jaen, Oliveira, Gabriel Melo, de Souza, Elen Mello, Hammer, Erica Ripoll, da Silva, Patricia Bernardino, Daliry, Anissa, Araujo, Julianna Siciliano, Britto, Constança, Rodrigues, Ana Carolina Mondaine, Liu, Zongying, Farahat, Abdelbasset A., Kumar, Arvind, Boykin, David W., de Nazaré Correia Soeiro, Maria
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264605/
https://ncbi.nlm.nih.gov/pubmed/22291940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030356
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