Global Analysis of the Staphylococcus aureus Response to Mupirocin

In the present study, we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRS), leading to the accumulation of uncharged isoleucyl-tRNA and eventually the synthesis of (p)ppGpp. The...

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Hlavní autoři: Reiß, Swantje, Pané-Farré, Jan, Fuchs, Stephan, François, Patrice, Liebeke, Manuel, Schrenzel, Jacques, Lindequist, Ulrike, Lalk, Michael, Wolz, Christiane, Hecker, Michael, Engelmann, Susanne
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264241/
https://ncbi.nlm.nih.gov/pubmed/22106209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05363-11
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